克罗米酚对男性较差促性腺素性功能减退症有效

纽约市（早些时候卫生特别版）1同年四日报道：据登载在12同年出特别版的《生育与生孩子》杂志的一项调查结果援引克罗米胺对一小低促性腺素性基本功能大不如前的未幼小病症十分困难。来自伯明翰新泽西大学的该调查结果的第一作者Scott J. Whitten哈佛大学在接受路透新闻社采访时说道：“原发性或获得性HH病症在接受触犯性相当大和更为昂贵的放射治疗（例如注射促性腺激素类）以前同步进行4个同年的克罗米胺试验性放射治疗是十分困难的。”Whitten哈佛大学和同事学术研究了克罗米胺对10名HH未幼小病症（HH是导致未幼小生孩子的少见因素）是否有效。调查结果引述克罗米胺放射治疗1年后，4名贝尔(高氏)综合症病症里面只有一名病症的生殖溶解度增加而全小脑基本功能大不如前症病症的生殖缺少症状均未得到改善。相反，该调查结果援引3名幼小中风的原发性HH未幼小病症经过3个同年克罗米胺的放射治疗生殖溶解度有了明显增加。目以前为止该组病症才有两名完全恢复了受孕。Whitten哈佛大学说道：“除非对克罗米胺放射治疗未反应，我们不会因为征状终止对病症使用该药物。”最后作者概述说道：“因为条件有限，对HH病症促性腺激素类药物和克罗米胺的随机学术研究不足以同步进行，然而利用多系列的严格同样基准对病症同步进行分级可能试图进一步验证克罗米胺完全恢复未幼小低受孕的有效性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编辑：蓝色幻想

编辑： 张靖